• Researchers prepared nanoscale borate bioactive glass

    Recently, * * Junfeng, a researcher of the strong magnetic field center of Hefei Institute of Physical Sciences, Chinese Academy of Sciences, and Zhang Teng, a professor of Fuzhou University, cooperated to prepare nanoscale borate bioactive glass relying on a steady-state strong magnetic field experimental device( nano-HCA@BG )This Bioglass not only greatly reduces the biological toxicity of borate Bioglass and improves the biocompatibility of the glass, but also significantly promotes the effect of borate Bioglass on skin repair, which is expected to become the next generation of skin wound repair dressing. Relevant achievements were published in the Chemical Engineering Journal.

    Skin is one of the important organs with a large area of human body. Skin damage not only affects the physiological function of human body, but also is * * life-threatening * *. At present, the field of skin tissue repair has become a hot spot in biomedical research. Borate Bioglass is a glass with boron (b) element as the matrix of glass network, which can achieve specific physiological functions. It has good doping and degradability, and shows great potential in the field of skin tissue repair. The mechanism by which borate Bioglass exerts its physiological functions is that boron, calcium and other elements in the components will be released into the body fluid after metabolism. These elements can stimulate angiogenesis and then promote wound healing. However, borate Bioglass still has some problems: first, borate Bioglass will release a large number of basic ions, and the explosive release of these ions will change the acid-base environment of the tissues around the glass material, thereby inhibiting cell proliferation. In addition, the effective specific surface area of micron borate Bioglass in contact with tissue at the wound is small, and the ions on the glass surface are not conducive to the deposition of collagen, so scars are easy to form at the wound after healing. Therefore, it is an urgent problem to prepare a nano-sized borate Bioglass without biological toxicity and with excellent biological properties.

    In this study, researchers innovatively used the flow relative melting method to prepare micron level borate Bioglass for in vitro pre-treatment, and finally obtained nanometer level (~ 50nm) borate Bioglass with amorphous HCA layer on its surface( Nano-HCA@BG ). During the treatment, ions (po43- and co32-) in the mobile phase will deposit on the surface of the glass to form an amorphous HCA layer, effectively inhibiting the rapid release of boron and calcium in the remaining glass, thereby reducing the biological toxicity of the glass itself to cells. In addition, HCA is an important inorganic component in bone, which has good biological compatibility and can accelerate the induction of collagen synthesis in tissues.

    The results of in vitro degradation experiments, cell experiments and animal experiments show that compared with the existing 45s5@, hydroxyapatite and micron grade borate Bioglass, nano-HCA@BG The slow-release boron, calcium and other elements not only effectively accelerated the migration of cells at the wound, but also upregulated the expression of vascular related growth factors at the wound. In addition, the amorphous HCA layer on the surface of glass not only reduces the rapid release of glass, but also promotes the deposition of collagen at the wound, thus promoting the wound healing more rapidly.

  • Copyright: Xinxiang Zhonghe Chemical Co., Ltd